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TIXiMED, Inc. is focused on developing and commercializing TXNIP inhibiting medication as a first-of-its-kind oral therapeutic for Type 1 and Type 2 diabetes. TIXiMED is the exclusive license holder for the patent (composition of matter and method of use) surrounding TIX100, a novel small molecule that normalizes pancreatic beta cell TXNIP, a detrimental protein elevated in Type 1 and Type 2 diabetes. Increased TXNIP causes pancreatic islet dysfunction and death of insulin-producing beta cells and thereby contributes to the development and progression of diabetes. Diabetes affects more than half a billion people worldwide. Those affected by Type 1 diabetes are dependent on multiple daily insulin injections or continuous insulin infusions to stay alive and manage their blood sugar. Oral anti-diabetic drugs are only approved for Type 2 diabetes, but can be associated with multiple side effects, underlining the need for novel and better oral diabetes medications for Type 1 and Type 2 diabetes. TXNIP inhibition has recently been demonstrated to be an effective and safe therapeutic approach in adults and children with recent onset Type 1 diabetes and TIX100 shows beneficial, anti-diabetic effects in 4 different mouse models. Advantages of TIX100 include oral availability, no associated hypoglycemia or weight gain, potent inhibition of detrimental TXNIP in human islets, and a favorable pharmacokinetic and safety profile. In addition, TIX100 inhibits excessive glucagon secretion and hepatic glucose production and protects against fatty liver. Thus, TIX100 holds promise for durable, weight-neutral improvement in glycemic control in Type 1 and Type 2 diabetes by targeting common underlying pathology and promoting patients own islet cell health.
Maison Albert Bichot, founded in 1831 in Beaune, is a family independent wine artisan run by the 6th generation. Its vineyards include 6 prestigious estates totaling more than 100 hectares (250 acres): - Domaine Long-Depaquit in Chablis (65 ha – 160 acres) - Domaine du Clos Frantin in Nuits-Saint-Georges (7,5 ha – 18,5 acres) - Château-Gris in Nuits-Saint-Georges (3,5 ha – 8,5 acres) - Domaine du Pavillon in Pommard (15 ha – 37 acres) - Domaine Adélie in Mercurey (7,8 ha – 11 acres) - Domaine de Rochegrès in Moulin-à-Vent (5,2 ha – 13 acres) We practise sustainable and organic viticulture in our vineyards. And starting with the 2018 vintage, all the wines from our Côte dOr and Mercurey estates will bear the certified "organic wine" label. We have a winery and a cellar in each of Burgundys major viticultural regions, where a dedicated team vinifies and ages our precious wines. Aware of the richness of the legacy that has been passed on to us, we want them to be imbued with the terroir and the characteristics of the village they hail from. The same care is taken with the grapes grown in our plots as with those purchased from our partner growers. All of the wines that bear the Albert Bichot signature benefit from the same know-how and meticulousness. Within the last 10 years, we were awarded twice the Best International Red winemaker (2004 & 2017) and White Winemaker (2011) trophy by the International Wine Challenge.
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