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INTERMOUNTAIN CONSTRUCTION INC is a Idaho Falls, ID-based company in the Business Services sector.
Nickola and Nickola is a Flint, MI-based company in the Business Services sector.
TIXiMED, Inc. is focused on developing and commercializing TXNIP inhibiting medication as a first-of-its-kind oral therapeutic for Type 1 and Type 2 diabetes. TIXiMED is the exclusive license holder for the patent (composition of matter and method of use) surrounding TIX100, a novel small molecule that normalizes pancreatic beta cell TXNIP, a detrimental protein elevated in Type 1 and Type 2 diabetes. Increased TXNIP causes pancreatic islet dysfunction and death of insulin-producing beta cells and thereby contributes to the development and progression of diabetes. Diabetes affects more than half a billion people worldwide. Those affected by Type 1 diabetes are dependent on multiple daily insulin injections or continuous insulin infusions to stay alive and manage their blood sugar. Oral anti-diabetic drugs are only approved for Type 2 diabetes, but can be associated with multiple side effects, underlining the need for novel and better oral diabetes medications for Type 1 and Type 2 diabetes. TXNIP inhibition has recently been demonstrated to be an effective and safe therapeutic approach in adults and children with recent onset Type 1 diabetes and TIX100 shows beneficial, anti-diabetic effects in 4 different mouse models. Advantages of TIX100 include oral availability, no associated hypoglycemia or weight gain, potent inhibition of detrimental TXNIP in human islets, and a favorable pharmacokinetic and safety profile. In addition, TIX100 inhibits excessive glucagon secretion and hepatic glucose production and protects against fatty liver. Thus, TIX100 holds promise for durable, weight-neutral improvement in glycemic control in Type 1 and Type 2 diabetes by targeting common underlying pathology and promoting patients own islet cell health.
TrinCan is engaged in oil and gas production and exploration, as well as mining exploration. The Company holds non-operating working interests of between 25 and 50 percent in a group of oil leases 40 kilometres south of Lloydminster, Saskatchewan, with net production of between 20 and 30 barrels of oil per day. It also holds 93.3% working interest on a lease on 1¾ sections in northwestern Alberta, referred to as the Nipisi project. In mining exploration, the Company has a 60% working interest in a group of optioned properties at Tashota, 215 kilometres northeast of Thunder Bay, Ontario. The 12,000-acre Tashota Project includes a gold-bearing zone known as the Paulpic deposit, which has a NI43-101 compliant inferred mineral resource of 68,900 ounces of gold at a grade of 8.24 grams of gold per tonne. The Company also holds an option to acquire 100% of the 920-acre Maki gold property near Beardmore, Ontario, as well as a 100% interest in the Opinaca 2 gold prospect covering approximately 18,000 acres in the James Bay area of northern Québec. The Opinaca 2 property is 15 kilometres southwest of Goldcorp's Éléonore/Roberto gold deposit, scheduled to commence production in 2014.
Borum Photographics Inc is a Nashville, TN-based company in the Business Services sector.