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TIXiMED, Inc. is focused on developing and commercializing TXNIP inhibiting medication as a first-of-its-kind oral therapeutic for Type 1 and Type 2 diabetes. TIXiMED is the exclusive license holder for the patent (composition of matter and method of use) surrounding TIX100, a novel small molecule that normalizes pancreatic beta cell TXNIP, a detrimental protein elevated in Type 1 and Type 2 diabetes. Increased TXNIP causes pancreatic islet dysfunction and death of insulin-producing beta cells and thereby contributes to the development and progression of diabetes. Diabetes affects more than half a billion people worldwide. Those affected by Type 1 diabetes are dependent on multiple daily insulin injections or continuous insulin infusions to stay alive and manage their blood sugar. Oral anti-diabetic drugs are only approved for Type 2 diabetes, but can be associated with multiple side effects, underlining the need for novel and better oral diabetes medications for Type 1 and Type 2 diabetes. TXNIP inhibition has recently been demonstrated to be an effective and safe therapeutic approach in adults and children with recent onset Type 1 diabetes and TIX100 shows beneficial, anti-diabetic effects in 4 different mouse models. Advantages of TIX100 include oral availability, no associated hypoglycemia or weight gain, potent inhibition of detrimental TXNIP in human islets, and a favorable pharmacokinetic and safety profile. In addition, TIX100 inhibits excessive glucagon secretion and hepatic glucose production and protects against fatty liver. Thus, TIX100 holds promise for durable, weight-neutral improvement in glycemic control in Type 1 and Type 2 diabetes by targeting common underlying pathology and promoting patients own islet cell health.
Beacon Construction Services is a Lutz, FL-based company in the Business Services sector.
Visit Cincy is a destination marketing organization that drives travel to create ongoing economic impact and vitality for the Cincy Regions people, businesses and communities in which we serve. Whether for leisure travelers or meeting professionals, Visit Cincy promotes distinctively memorable experiences that attract, delight, and connect people to the diverse heritage, rich history, deep culture, and values that are uniquely Cincinnati. Our overall goal: supporting the residents of the Cincy region through increased tax revenue and direct spending in area businesses by visitors, meeting planners and convention goers. This goal is accomplished through strategic sales, marketing, event services, destination leadership, diversity and inclusion initiatives and tourism industry engagement strategies.
Syntechs is a Boca Raton, FL-based company in the Business Services sector.
John W Hansen and Associates is a Ogden, UT-based company in the Business Services sector.