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TIXiMED, Inc. is focused on developing and commercializing TXNIP inhibiting medication as a first-of-its-kind oral therapeutic for Type 1 and Type 2 diabetes. TIXiMED is the exclusive license holder for the patent (composition of matter and method of use) surrounding TIX100, a novel small molecule that normalizes pancreatic beta cell TXNIP, a detrimental protein elevated in Type 1 and Type 2 diabetes. Increased TXNIP causes pancreatic islet dysfunction and death of insulin-producing beta cells and thereby contributes to the development and progression of diabetes. Diabetes affects more than half a billion people worldwide. Those affected by Type 1 diabetes are dependent on multiple daily insulin injections or continuous insulin infusions to stay alive and manage their blood sugar. Oral anti-diabetic drugs are only approved for Type 2 diabetes, but can be associated with multiple side effects, underlining the need for novel and better oral diabetes medications for Type 1 and Type 2 diabetes. TXNIP inhibition has recently been demonstrated to be an effective and safe therapeutic approach in adults and children with recent onset Type 1 diabetes and TIX100 shows beneficial, anti-diabetic effects in 4 different mouse models. Advantages of TIX100 include oral availability, no associated hypoglycemia or weight gain, potent inhibition of detrimental TXNIP in human islets, and a favorable pharmacokinetic and safety profile. In addition, TIX100 inhibits excessive glucagon secretion and hepatic glucose production and protects against fatty liver. Thus, TIX100 holds promise for durable, weight-neutral improvement in glycemic control in Type 1 and Type 2 diabetes by targeting common underlying pathology and promoting patients own islet cell health.
The Democratic Senatorial Campaign Committee is the only committee solely dedicated to electing a Democratic Senate. From organizing to fundraising to candidate recruitment, the DSCC works around-the-clock to re-elect Democratic senators and send new leaders to Washington who will move our country forward.
Modular Systems Installations is a Freehold, NJ-based company in the Business Services sector.
Corporate Services and Associates, L.L.C. is a Las Vegas, NV-based company in the Business Services sector.
CME Associates is a well-established integrated engineering firm located in New Jersey, with over 40 years of experience. The company operates from eight offices and employs around 300 professionals, making it a key player in the engineering industry. Recently, CME Associates partnered with the Trilon Group to support its growth and expansion while upholding its commitment to quality service. The firm offers a wide range of engineering services, including civil, environmental, geotechnical, and structural engineering. They also provide surveying, planning, and landscape architecture services. CME Associates serves a diverse clientele, including government agencies, municipalities, and private entities, having collaborated with over 125 local organizations in New Jersey. With reported revenues of approximately $86.9 million, CME Associates demonstrates a strong financial presence in the engineering sector.