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TIXiMED, Inc. is focused on developing and commercializing TXNIP inhibiting medication as a first-of-its-kind oral therapeutic for Type 1 and Type 2 diabetes. TIXiMED is the exclusive license holder for the patent (composition of matter and method of use) surrounding TIX100, a novel small molecule that normalizes pancreatic beta cell TXNIP, a detrimental protein elevated in Type 1 and Type 2 diabetes. Increased TXNIP causes pancreatic islet dysfunction and death of insulin-producing beta cells and thereby contributes to the development and progression of diabetes. Diabetes affects more than half a billion people worldwide. Those affected by Type 1 diabetes are dependent on multiple daily insulin injections or continuous insulin infusions to stay alive and manage their blood sugar. Oral anti-diabetic drugs are only approved for Type 2 diabetes, but can be associated with multiple side effects, underlining the need for novel and better oral diabetes medications for Type 1 and Type 2 diabetes. TXNIP inhibition has recently been demonstrated to be an effective and safe therapeutic approach in adults and children with recent onset Type 1 diabetes and TIX100 shows beneficial, anti-diabetic effects in 4 different mouse models. Advantages of TIX100 include oral availability, no associated hypoglycemia or weight gain, potent inhibition of detrimental TXNIP in human islets, and a favorable pharmacokinetic and safety profile. In addition, TIX100 inhibits excessive glucagon secretion and hepatic glucose production and protects against fatty liver. Thus, TIX100 holds promise for durable, weight-neutral improvement in glycemic control in Type 1 and Type 2 diabetes by targeting common underlying pathology and promoting patients own islet cell health.
With offices in New York and Los Angeles, Paduano & Weintraub LLP is a boutique full-service litigation firm dedicated to providing its clients with the highest level of service and meeting all of their litigation needs. We are committed to providing innovative and creative solutions and seasoned legal advice. We zealously represent our clients as if their problems were our own. Litigation often can be very stressful, time consuming and expensive. Our job is to make our clients comfortable with the process, and to customize a litigation strategy that best achieves their goals, whether it is to quickly and quietly resolve a dispute, get a complaint dismissed through motion practice, or crush an adversary at trial. Since 2000, Paduano & Weintraub has offered quality legal services at a reasonable cost. We are a civil litigation and appellate firm that represents clients in the areas of business, financial services and employment litigation, employment counseling, and restrictive covenants.
Exolaunch (Germany, USA) is a global supplier of rideshare launch, deployment, in-space logistics, and integration services for the NewSpace ecosystem. With a decade of flight heritage and 320+ satellites deployed across 21 missions on launch vehicles around the world, Exolaunch has an industry insight it can leverage to develop one-stop-shop solutions tailored towards meeting customer needs and addressing market trends. Exolaunch executes launch services for NewSpace leaders, the worlds most innovative startups, research institutions, government organizations, and space agencies. Exolaunch manufactures lightweight and flight-proven separation systems to deliver integration and deployment services for small satellites. The company is also developing a line of environmentally-friendly orbital transfer vehicles named Reliant for the satellite last-mile transportation, in-space logistics and space debris removal. Exolaunch is committed to making space accessible for everyone and to promoting safe, sustainable and responsible use of space. For more information about Exolaunch, please visit: www.exolaunch.com or get in touch at info@exolaunch.com
St. Pius X High School is a Catholic college preparatory School of the Archdiocese of Santa Fe. We serve God and the community through faith, love and respect and inspire learning, leadership and service.
Alliance is a New York, NY-based company in the Business Services sector.