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TIXiMED, Inc. is focused on developing and commercializing TXNIP inhibiting medication as a first-of-its-kind oral therapeutic for Type 1 and Type 2 diabetes. TIXiMED is the exclusive license holder for the patent (composition of matter and method of use) surrounding TIX100, a novel small molecule that normalizes pancreatic beta cell TXNIP, a detrimental protein elevated in Type 1 and Type 2 diabetes. Increased TXNIP causes pancreatic islet dysfunction and death of insulin-producing beta cells and thereby contributes to the development and progression of diabetes. Diabetes affects more than half a billion people worldwide. Those affected by Type 1 diabetes are dependent on multiple daily insulin injections or continuous insulin infusions to stay alive and manage their blood sugar. Oral anti-diabetic drugs are only approved for Type 2 diabetes, but can be associated with multiple side effects, underlining the need for novel and better oral diabetes medications for Type 1 and Type 2 diabetes. TXNIP inhibition has recently been demonstrated to be an effective and safe therapeutic approach in adults and children with recent onset Type 1 diabetes and TIX100 shows beneficial, anti-diabetic effects in 4 different mouse models. Advantages of TIX100 include oral availability, no associated hypoglycemia or weight gain, potent inhibition of detrimental TXNIP in human islets, and a favorable pharmacokinetic and safety profile. In addition, TIX100 inhibits excessive glucagon secretion and hepatic glucose production and protects against fatty liver. Thus, TIX100 holds promise for durable, weight-neutral improvement in glycemic control in Type 1 and Type 2 diabetes by targeting common underlying pathology and promoting patients own islet cell health.
RESA Power, founded in 2003 and based in Houston, Texas, specializes in mission-critical power systems services. The company enhances the safety, reliability, and efficiency of electrical infrastructure and operates over 50 service locations across North America. RESA has experienced significant growth through strategic acquisitions, including the recent acquisition of HALCO Service Corporation, which bolstered its electrical testing and engineering capabilities. RESA Power offers a wide range of services, including preventative and predictive maintenance, electrical testing and diagnostics, systems integration, and transformer and switchgear servicing. The company also provides engineering solutions for optimizing power infrastructure and maintains an inventory of hard-to-find components to support legacy systems. Its diverse clientele includes industrial and commercial facilities, utilities, renewable energy providers, data centers, government entities, and electrical contractors. With a focus on employee ownership and strategic investments, RESA is well-positioned to address the growing demand for power infrastructure upgrades.
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