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Trevena is a publicly traded clinical stage biopharmaceutical company based in King of Prussia, PA, dedicated to the discovery and development of GPCR biased ligands. Established in late 2007, Trevena was created to translate groundbreaking research on GPCR signaling into a new generation of medicines. We have three programs in clinical development: TRV027, currently in phase 2 clinical testing for the treatment of acute heart failure; TRV130, currently in phase 2 testing for the intraveneous treatment of postoperative pain; and TRV734, currently in phase 1 testing for oral treatment of acute and chronic pain. In addition, Trevena has built an early-stage portfolio of drug discovery programs currently in lead optimization. G protein coupled receptors are the targets for more than 30% of all currently marketed therapeutics. There is significant opportunity to improve upon currently marketed GPCR drugs because many have limited efficacy and undesirable adverse effects, which can prevent broader use. Furthermore, many GPCRs are linked to diseases but cannot be translated into medicines because of specific target-related adverse effects. Trevena's biased ligand approach has the potential to address these problems across a wide range of receptors and therapeutic areas.
Octave is developing a comprehensive, first-in-class Care Management Platform.
Lygos employs cutting edge synthetic biology techniques to generate microbial catalysts to convert agricultural feedstocks into fine and commodity chemicals. Our robust high throughput screening and strain construction facilitates the rapid optimization of pathways to convert cheap and renewable feedstock to high value chemicals.
The greatest health threats require more than an all-or-nothing approach. Nano represents a multi-layered set of solutions to usher in a new era in proactive, persistent health protection.
Adare Pharma Solutions is a global contract development and manufacturing organization (CDMO) focused on oral dosage forms for the pharmaceutical industry. The company offers integrated services that span from product development to commercial manufacturing and packaging, with a strong emphasis on small molecule pharmaceuticals. With around 800 employees and seven facilities in the United States and Europe, Adare is well-equipped to serve markets worldwide. The company specializes in technologies such as taste masking, customized release, and solubility enhancement, addressing unique formulation challenges. Adares product development services include formulation development, analytical method validation, and support for various regulatory submissions. Their manufacturing capabilities encompass a range of processes, including granulation, coating, and high potency manufacturing. Additionally, Adare operates a dedicated packaging facility that provides high-speed packaging solutions. The company serves a diverse customer base, including branded, specialty, generic, and veterinary pharmaceutical segments, and is committed to maintaining high regulatory standards across all operations.